Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Cis tert-Butyl 4-aminocyclohexylcarbamate | HCID 2756050 | — |
| Reactant | 7-Chloro-6-nitrothieno[3,2-b]pyridine | HCID 14207950 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 86717481 | HCID 86717481 | — |
Reaction Steps
A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (118 mg, 0.550 mmol), tert-butyl (4-aminocyclohexyl)carbamate (140 mg, 0.66 mmol) and triethylamine (0.23 mL, 1.6 mmol) in isopropyl alcohol (5 mL) was heated at 100° C. for 1 h. The mixture was concentrated to give the desired product as a mixture of cis- & trans-isomer mixtures to be used in the next step directly. LCMS calculated for C18H25N4O4S (M+H)+: m/z=393.2. Found: 393.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09181271B2 |
|---|
| Source dataset | uspto-grants-2015_11 |
|---|
| ORD ID | ord-1f4019a142a04e728d70e02b5df3768d |
|---|
| Source note | uspto-grants-2015_11 |
|---|
