反应详情

Ethyl {trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acetate (160 mg, 0.44 mmol) and 10% Pd/C (20 mg) in methanol (4 mL) was subjected to balloon pressure of H2 at room temperature for 2 h. The mixture was filtered. The filtrate was concentrated and purified on silica gel column (eluting with 0-10% MeOH in methylene chloride) to give the desired product. LCMS calculated for C17H24N3O2S (M+H)+: m/z=334.2. Found: 334.1.

1. customat room temperature
2. customfor 2 h
3. filtrationThe mixture was filtered
4. concentrationThe filtrate was concentrated
5. custompurified on silica gel column (eluting with 0-10% MeOH in methylene chloride)