HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 712039Generated: October 29, 2026
Triethylamine → 3-{3-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acrylonitrile
https://huagongshe.com/reaction/712039
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 7-Chloro-6-nitrothieno[3,2-b]pyridine | HCID 14207950 | — |
| Reactant | 3-(3-Aminocyclohexyl)acrylonitrile hydrochloride | HCID 86717492 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 3-{3-[(6-Nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acrylonitrile | HCID 86717494 | — |
Reaction Steps
A mixture of 3-(3-aminocyclohexyl)acrylonitrile hydrochloride (0.090 g, 0.48 mmol), 7-chloro-6-nitrothieno[3,2-b]pyridine (0.085 g, 0.40 mmol) and triethylamine (0.22 mL, 1.6 mmol) in isopropyl alcohol (0.9 mL) was heated at 90° C. for 1 h. The mixture was concentrated to give the desired product to be used in the next step directly. LCMS calculated for C16H17N4O2 (M+H)+: m/z=329.1. Found: 329.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09181271B2 |
|---|
| Source dataset | uspto-grants-2015_11 |
|---|
| ORD ID | ord-4f1ad327ffbd42b096cbbb49504c482e |
|---|
| Source note | uspto-grants-2015_11 |
|---|
