Triethyl orthoacetate → HCID 86717525, compound

HRID 712066Notes

Reaction equation

HRID 712066 reaction equation
[NH2:1][C:2]1[C:3]([NH:11][C@H:12]2[CH2:17][CH2:16][C@H:15]([CH2:18][C:19]#[N:20])[C@@H:14]([O:21][CH3:22])[CH2:13]2)=[C:4]2[S:10][CH:9]=[CH:8][C:5]2=[N:6][CH:7]=1.[C:23](OCC)(OCC)(OCC)[CH3:24]>>[CH3:23][C:24]1[N:11]([C@H:12]2[CH2:17][CH2:16][C@H:15]([CH2:18][C:19]#[N:20])[C@@H:14]([O:21][CH3:22])[CH2:13]2)[C:3]2=[C:4]3[S:10][CH:9]=[CH:8][C:5]3=[N:6][CH:7]=[C:2]2[N:1]=1

Participants

3

Reactant 2

HCID 66221Triethyl orthoacetateHCID 86717519HCID 86717519, compound

Product 1

HCID 86717525HCID 86717525, compound

Procedure

This compound was prepared according to the procedure of Example 34, steps 12, using {(1R,2S,4S)-4-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]-2-methoxycyclohexyl}acetonitrile (racemic) and triethyl orthoacetate as the starting material. LCMS calculated for C18H21N4OS (M+H)+: m/z=341.1. Found: 341.1.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-371d8bbdbcfc484e9ad8c19f249c594f
Source dataset
uspto-grants-2015_11
Patent number
US09181271B2

Reaction notes

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