p-Toluenesulfonic acid monohydrate → HCID 86717561, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of {8-[(6-aminothieno[3,2-b]pyridin-7-yl)amino]-1,4-dioxaspiro[4.5]dec-8-yl}methanol (90.0 mg, 0.268 mmol), ethyl orthoformate (112 μL, 0.671 mmol), and p-toluenesulfonic acid monohydrate (5.1 mg, 0.027 mmol) in toluene (3.0 mL) was stirred at 85° C. overnight. The mixture was diluted with EtOAc, then washed with sat. sodium bicarbonate and brine. The organic layer was dried (Na2SO4), filtered and concentrated to give 50 mg (50%) of the desired product. LCMS calculated for C17H20N3O3S (M+H)+: m/z=346.1. Found: 346.0.

Provenance & Evidence