1-tert-Butyl 4-ethyl 4-methylpiperidine-1,4-dicarboxylate → Ethyl 4-methylpiperidine-4-carboxylate hydrochloride

HRID 712160Notes

Reaction equation

HRID 712160 reaction equation
[CH3:1][C:2]1([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.[ClH:20].O1CCOCC1>O1CCOCC1>[ClH:20].[CH3:1][C:2]1([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 162182761-tert-Butyl 4-ethyl 4-methylpiperidine-1,4-dicarboxylateHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 19361804Ethyl 4-methylpiperidine-4-carboxylate hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To an ice-cold solution of O1-tert-butyl O4-ethyl 4-methylpiperidine-1,4-dicarboxylate (1 g, 3.68 mmol) in 1,4-dioxane (10 mL) was added HCl-1,4-dioxane (4.0 M, 15 mL) solution. The mixture was stirred at rt for 30 minutes. After completion of reaction (by TLC), solvent was evaporated to obtain brown solid material (0.90 g) that was carried forward to the next step without purification. MS: 172.16 [M+H]+.

Workup

  1. customAfter completion of reaction (by TLC), solvent
  2. customwas evaporated

Sources & evidence

ORD record
ord-299fe4dfdfa74898a0516eeaf7e186e2
Source dataset
uspto-grants-2015_11
Patent number
US09181234B2

Reaction notes

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