Ethylamine → (2,3,5-Tribromo-4-methoxy-phenyl)thiourea

HRID 712189Notes

Reaction equation

HRID 712189 reaction equation
[Br:1][C:2]1[C:7]([Br:8])=[C:6]([O:9][CH3:10])[C:5]([Br:11])=[CH:4][C:3]=1[NH:12][C:13]([NH:15]C(=O)OCC)=[S:14].C(N)C>>[Br:1][C:2]1[C:7]([Br:8])=[C:6]([O:9][CH3:10])[C:5]([Br:11])=[CH:4][C:3]=1[NH:12][C:13]([NH2:15])=[S:14]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 86663965Ethyl N-[(2,3,5-tribromo-4-methoxy-phenyl)carbamothioyl]carbamate

Product 1

HCID 86663966(2,3,5-Tribromo-4-methoxy-phenyl)thiourea

Procedure

Ethyl N-[(2,3,5-tribromo-4-methoxy-phenyl)carbamothioyl]carbamate (500 mg, 1.02 mmol) was dissolved in ethylamine solution (5.09 mL, 10.18 mmol, 2 M in THF) and stirred at rt overnight. The mixture was concentrated to dryness under reduced pressure to give the desired compound as an off white solid. The mixture was used with no further purification in the next step. m/z: 416.83/418.84/420.83/422.83 [M+H]+.

Workup

  1. concentrationThe mixture was concentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-c09e4979c7b846c69b5eff87f87c6178
Source dataset
uspto-grants-2015_11
Patent number
US09181234B2

Reaction notes

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