1,4-Dioxane hydrochloride → Methyl 4-hydroxy-3-methyl-piperidine-3-carboxylate hydrochloride

Participants

Reaction Steps

To an ice-cold solution of O1-tert-butyl O3-methyl 4-hydroxy-3-methyl-piperidine-1,3-dicarboxylate (0.5 g, 1.83 mmol) in 1,4-dioxane (10 mL) was added HCl-dioxane (4 M, 5 mL) solution. The resulting mixture was stirred at rt for 30 min. After reaction completion (by TLC), solvent was evaporated to obtain the desired product as a solid (0.4 g). MS: 174.13 [M+H]+.

Provenance & Evidence