Hexane → HCID 66977263, compound

Participants

Reaction Steps

To a solution of ethyl 3,4-dimethylpiperidine-4-carboxylate (0.2 g, 1.08 mmol) in EtOH (7 mL) was added DIPEA (0.6 mL, 3.24 mmol) at rt. The mixture was stirred at rt for 10 min followed by addition of 5-bromo-2-chloropyrimidine (0.21 g, 1.08 mmol) then heated up to 70° C. for 1 h. After reaction completion (by TLC), solvent was evaporated and the crude residue was purified over 100-200 M silica-gel using 10% EtOAc:hexane to obtain the desired product as a yellow solid (0.33 g, 95% yield). MS: 341.03 [M+H]+.

Provenance & Evidence