Acetic Acid Mixture with Hydrobromic Acid → HCID 66977230, compound

Participants

Reaction Steps

A solution of 1-(5-bromopyrimidin-2-yl)-4-phenylpiperidine-4-carbonitrile (0.31 g, 0.9 mmol) in HBr-acetic acid (12 mL) was refluxed for 16 h. After completion of reaction (by TLC), the mixture was poured into 100 mL of ice cold water and extracted with EtOAc (3×150 mL). The combined organics were washed with brine, dried over anhydrous Na2SO4, filtered and evaporated to obtain the desired product as a white solid (0.12 g). MS: 361.15 [M+H]+.

Provenance & Evidence