1,4-Dioxane hydrochloride → HCID 66977146, compound

HRID 712216Notes

Reaction equation

HRID 712216 reaction equation
[CH3:1][S:2]([C:5]1([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1)(=[O:4])=[O:3].[ClH:23].O1CCOCC1>O1CCOCC1>[ClH:23].[CH3:1][S:2]([C:5]1([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 66977242HCID 66977242, compound

Product 1

HCID 66977146HCID 66977146, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To an ice-cold solution of 1-tert-butyl 4-ethyl 4-(methylsulfonyl)piperidine-1,4-dicarboxylate (0.20 g, 0.60 mmol) in 1,4-dioxane (5.0 mL) was added HCl-dioxane (4.0 M, 1.0 mL) solution and the resulting mixture stirred at rt for 30 min. After completion of reaction (by TLC), solvent was evaporated to obtain a brownish solid material (0.20 g) that was carried forward to the next step without further purification. MS: 236.11 [M+H]+.

Workup

  1. customAfter completion of reaction (by TLC), solvent
  2. customwas evaporated

Sources & evidence

ORD record
ord-f49bb446fe7d4d80ac091b39248fd1a4
Source dataset
uspto-grants-2015_11
Patent number
US09181234B2

Reaction notes

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