Hydrochloric Acid → HCID 66977029, compound

Participants

Reaction Steps

1-tert-Butyl 4-ethyl 4-cyclopropylpiperidine-1,4-dicarboxylate (164 mg, 0.55 mmol) was stirred at rt in 4M Hydrogen chloride in dioxane (2 mL, 8 mmol) for 35 minutes. The volatiles were removed and the residue dried under high vacuum to afford the desired product as a crystalline solid (129 mg). 1H NMR (MeOD) δ 4.22 (q, J=7.1 Hz, 2H), 3.38 (dd, J=10.5, 2.7 Hz, 2H), 2.99-2.82 (m, 2H), 2.23 (dd, J=14.6, 2.2 Hz, 2H), 1.74 (td, J=14.3, 4.2 Hz, 2H), 1.29 (t, J=7.1 Hz, 3H), 1.11-0.96 (m, 1H), 0.50-0.43 (m, 2H), 0.43-0.36 (m, 2H).

Provenance & Evidence