4-Piperidinecarboxylicacid, 4-hydroxy-1-(phenylmethyl)- → 4-hydroxypiperidine-4-carboxylic Acid

Participants

Reaction Steps

To the solution of 1-benzyl-4-hydroxypiperidine-4-carboxylic acid (1.0 g, 4.25 mmol) in EtOH (15.0 mL) was added palladium hydroxide (0.40 g, 40% w/w) at rt and the mixture stirred at rt for 20 h under H2 atmosphere. After completion of reaction (by TLC) the mixture was passed through celite and the solvent evaporated. The crude (0.70 g) residue was carried forward for next step without further purification. MS: 145.99 [M+H]+.

Provenance & Evidence