Hydrochloric Acid → Ethyl 4-hydroxypiperidine-4-carboxylate

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-hydroxypiperidine-4-carboxylic acid (1.20 g, 8.26 mmol) in EtOH (30 ml) was added conc. HCl (5 ml) at rt and the mixture heated up to 80° C. for 2-3 h. After completion (by TLC), solvent was evaporated under reduced pressure to obtain the desired product (1.20 g, crude) which was carried forward for next step without further purification. 1H NMR (D2O): δ 4.20 (q, J=7.20 Hz, 2H), 3.28 (M, 4H), 2.22 (m, 2H), 1.91 (m, 2H), and 1.22 (t, J=7.20 Hz, 3H).

Provenance & Evidence