反应详情

Bromine (56 μl, 1.09 mmol) was added to a suspension of 3-(carbamothioylamino)-5-methoxy-benzoic acid (248 mg, 1.09 mmol) in chloroform (7 mL). The reaction was stirred at ambient temperature resulting in large granules of solid material which were pulverized with a spatula. The chloroform was removed by pipette and the remaining solid was triturated with dichloromethane to give the product as a pale yellow solid, 200 mg, 81% yield.

1. customresulting in large granules of solid material which
2. customThe chloroform was removed by pipette
3. customthe remaining solid was triturated with dichloromethane