HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 712281Generated: October 29, 2026
Ethyl isocyanate → N-ethyl-2-(ethylcarbamoylamino)-5-methoxy-1,3-benzothiazole-7-carboxamide
https://huagongshe.com/reaction/712281
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl isocyanate | HCID 8022 | — |
| Reactant | 2-amino-N-ethyl-5-methoxy-1,3-benzothiazole-7-carboxamide | HCID 86663993 | — |
| Catalyst | Di-n-butyl diacetoxy tin | HCID 9798523 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-ethyl-2-(ethylcarbamoylamino)-5-methoxy-1,3-benzothiazole-7-carboxamide | HCID 86663994 | — |
Reaction Steps
Ethyl isocyanate (0.87 mL, 10.9 mmol) was added to a suspension of 2-amino-N-ethyl-5-methoxy-1,3-benzothiazole-7-carboxamide (549 mg, 2.18 mmol) and dibutyl tin diacetate (4 drops, catalytic amount) in dioxane (12 mL). The reaction was heated to 60° C. for 8 hours after which time LCMS indicated clean conversion to the desired product. The reaction solvent was removed in vacuo and the crude material used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09181234B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-a0e267211e0945af90b57580a3dae7ab |
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| Source note | uspto-grants-2015_11 |
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