1,4-Dioxane hydrochloride → HCID 86664007, compound

Participants

Reaction Steps

To an ice-cold solution of 4-((tert-butoxycarbonyl)amino)-1-(5-(2-(3-ethylureido)-7-(pyridin-2-yl)benzothiazol-5-yl)pyrimidin-2-yl)piperidine-4-carboxylic acid (0.02 g, 0.03 mmol) in 1,4-dioxane (2.0 mL) was added HCl-dioxane (4.0 M, 1.0 mL) solution and the reaction mixture was left to stir at rt for 30 min. After completion (by TLC), the solvent was evaporated to obtain a brownish solid material that was finally triturated with ether to afford Compound 128 (0.01 g) as a hydrochloride salt. 1H NMR (DMSO-d6): δ 1.11 (t, J=7.20 Hz, 3H), 1.87 (m, 2H), 2.11 (m, 2H), 3.19 (m, 2H), 3.40 (m, 2H), 3.93 (m, 2H), 4.12 (m, 2H), 6.99 (br s, 1H), 7.45 (m, 1H), 7.95 (br s, 2H), 8.25 (s, 1H), 8.49 (d, J=8.0 Hz, 1H), 8.62 (s, 2H), 8.80 (d, J=4.0 Hz, 1H), 8.97 (s, 1H) and 10.65 (br s, 1H). LCMS: 519.30 [M+H]+

Provenance & Evidence