反应详情

温度

50 °C

Ethyl 4-ethyl-1-[5-[2-(3-ethyl-5-methyl-2-oxo-1,3,5-triazinan-1-yl)-7-formyl-1,3-benzothiazol-5-yl]pyrimidin-2-yl]piperidine-4-carboxylate (33 mg, 0.058 mmol) was suspended in MeOH (2 mL) and treated with conc. H2SO4 (˜5 μL). The reaction was heated to 50° C. for 1.5 h then diluted with DCM and sat.NaHCO3(aq). The organic layer was separated and the aqueous layer extracted further with DCM (2×) before the combined DCM extracts were dried and the solvent evaporated to yield the crude product (35 mg). Crude product was used in the next step without further purification. MS: 557.16 [M+H]+.

1. customThe organic layer was separated
2. extractionthe aqueous layer extracted further with DCM (2×) before the combined DCM extracts
3. customwere dried
4. customthe solvent evaporated