Ethyl Acetate → HCID 66977297, compound

Participants

Reaction Steps

To a solution of ethyl 1-(5-(4-amino-3-nitro-5-(pyridin-2-yl)phenyl)pyrimidin-2-yl)-4-ethylpiperidine-4-carboxylate (0.70 g, 1.46 mmol) in EtOAc (20.0 mmol) was added Pd/C (0.14 g, 20% w/w) and the mixture stirred at rt under hydrogen for 16 h. After completion the reaction (by TLC), the mixture was filtered through celite, the filtrate concentrated under reduced pressure and triturated with Et2O to afford the desired product (0.65 g, 99%). 1H NMR (DMSO-d6): δ 8.61-8.62 (m, 1H), 8.58 (s, 2H), 7.86-7.88 (m, 2H), 7.28-7.30 (m, 1H), 7.11 (s, 1H), 6.84 (s, 1H), 6.16 (s, 2H), 4.78 (br s, 2H), 4.38-4.42 (m, 2H), 4.13-4.18 (m, 2H), 3.04-3.10 (m, 2H), 2.04-2.08 (m, 2H), 1.55-1.57 (m, 2H), 1.37-1.39 (m, 2H), 1.19 (t, J=7.20 Hz, 3H) and 0.83 (t, J=7.20 Hz, 3H). MS: 447.35 [M+H]+

Provenance & Evidence