HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 712375Generated: October 31, 2026
Thionyl Chloride → 4-Chloro-7-methoxyquinazolin-6-yl acetate
https://huagongshe.com/reaction/712375
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 6-Acetoxy-7-methoxy-3H-quinazolin-4-one | HCID 135681960 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Chloro-7-methoxyquinazolin-6-yl acetate | HCID 22022160 | — |
Reaction Steps
A suspension of 7-methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate (2.00 g), DMF (0.20 mL) and thionyl chloride (30 mL) was stirred at 70° C. for 3 h. The mixture was concentrated in vacuo, and the residue was used for the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09181277B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-a0cb960bfa2a472d98274a925c68df95 |
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| Source note | uspto-grants-2015_11 |
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