HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 712376Generated: October 29, 2026
3-Chloro-4-fluoroaniline → 4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate
https://huagongshe.com/reaction/712376
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Chloro-4-fluoroaniline | HCID 9708 | — |
| Reactant | 4-Chloro-7-methoxyquinazolin-6-yl acetate | HCID 22022160 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate | HCID 21098396 | 81% |
Reaction Steps
A suspension of 4-chloro-7-methoxyquinazolin-6-yl acetate (2.52 g), 3-chloro-4-fluoroaniline (1.49 g) and isopropanol (60 mL) was stirred at 88° C. for 5 h. The reaction mixture was cooled to room temperature, filtered to afford the desired compound as a solid (2.51 g, 81.00%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09181277B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-b84edcac32814e87aee3593358b1832d |
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| Source note | uspto-grants-2015_11 |
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