Hydrochloric Acid → 4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-ol

Participants

Reaction Steps

To a suspension of 4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate (2.51 g) and methanol (50 mL) was added 5 mol/L NaOH (5.00 mL) at room temperature. The reaction mixture was stirred at room temperature for 6 h, and was adjusted to pH 5 with 0.1 N HCl (aq). The mixture was filtered to give the title compound as a solid (1.99 g, 90.00%).

Provenance & Evidence