3-(Trifluoromethyl)-1,2,4-triazolo(4,3-a)pyrazine → 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-(1,2,4)triazolo(4,3-a)pyrazine

HRID 712379Notes

Reaction equation

HRID 712379 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[N:7]2[CH:8]=[CH:9][N:10]=[CH:11][C:6]2=[N:5][N:4]=1>CO.[Pd]>[F:12][C:2]([F:1])([F:13])[C:3]1[N:7]2[CH2:8][CH2:9][NH:10][CH2:11][C:6]2=[N:5][N:4]=1

Participants

4

Reactant 1

HCID 299234623-(Trifluoromethyl)-1,2,4-triazolo(4,3-a)pyrazine

Product 1

HCID 101764893-(Trifluoromethyl)-5,6,7,8-tetrahydro-(1,2,4)triazolo(4,3-a)pyrazine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine (1.60 g) in methanol (20 mL) was added a catalytic amount of Pd/C. The suspension was stirred under H2 for 5 h, and then filtered. The filtrate was concentrated in vacuo to give a residue, which was used for next step without further purification.

Workup

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo
  3. customto give a residue, which
  4. customwas used for next step without further purification

Sources & evidence

ORD record
ord-8110480a3311460a8188d38255464ec7
Source dataset
uspto-grants-2015_11
Patent number
US09181277B2

Reaction notes

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