4-Fluoroaniline → 4-((4-Fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate

Participants

Role	Name	HCID	Charge
Reactant	4-Fluoroaniline	HCID 9731	—
Reactant	4-Chloro-7-methoxyquinazolin-6-yl acetate	HCID 22022160	—
Solvent	Isopropanol	HCID 3776	—
Product	4-((4-Fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate	HCID 86729467	85.9%

Reaction Conditions

Temperature	83 °C

Reaction Steps

A suspension of 4-chloro-7-methoxyquinazolin-6-yl acetate (2.17 g), 4-fluoroaniline (1.00 mL) and isopropanol (40 mL) was stirred at 83° C. overnight. The reaction mixture was cooled to room temperature and filtered, the residue was washed with 100 mL of isopropanol and dried to afford the desired compound as a solid (2.42 g, 85.90%)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09181277B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-ddb5447f0fd543b196c90d44a20b99ef
Source note	uspto-grants-2015_11