Hydrochloric Acid → 4-((3-Ethynyl-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol

Participants

Reaction Steps

To a suspension of 4-((3-ethynyl-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate (5.29 g) and methanol (30 mL) was added 5 mol/L NaOH (10.00 mL) at room temperature. The reaction mixture was stirred at room temperature for 4 h, and was adjusted to pH 7 with 0.1 N HCl (aq). The mixture was filtered to give the title compound as a white solid (3.90 g, 83.69%).

Provenance & Evidence