HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 712410Generated: October 30, 2026
Water → N-(3-ethynyl-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine
https://huagongshe.com/reaction/712410
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Bromo-3-chloropropane | HCID 8006 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-((3-Ethynyl-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol | HCID 45140542 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(3-ethynyl-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine | HCID 86729471 | 68% |
Reaction Steps
To a suspension of 4-((3-ethynyl-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol (3.90 g), K2CO3 (4.36 g) in DMF (30 mL) was added 1-bromo-3-chloropropane (3.80 mL) at rt, the mixture was stirred at 40° C. overnight. The reaction mixture was poured into water and filtered. The filter residue was purified by a silica gel column chromatography (eluting agent: 3:1 (v/v) PE/EA) to give the title compound as a white solid (3.30 g, 68.00%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09181277B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-9f1c9226a2704ffb9626b6ae3c8a63d1 |
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| Source note | uspto-grants-2015_11 |
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