Hydrochloric Acid → HCID 71573261, compound

Participants

Reaction Steps

To a solution of tert-butyl 1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate (0.50 g) was added a solution of HCl in EtOAc (10 mL). The reaction mixture was continued to stir at room temperature for 2 h and filtered to afford the title compound as a solid (0.28 g, 64.00%), HPLC: 98.79%. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 472.2 (M+1); 1H NMR (400 MHz, CDCl3) δ: 1.55-1.58 (m, 2H), 1.83-1.88 (m, 3H), 2.25 (t, J=5.7 Hz, 2H), 2.40-2.45 (m, 3H), 2.70-2.73 (m, 4H), 3.93 (s, 3H), 4.08 (t, J=5.4 Hz, 2H), 7.16 (s, 1H), 7.26 (s, 1H), 7.45 (s, 1H), 7.57-7.60 (m, 1H), 7.91-7.95 (m, 1H), 8.64 (s, 1H) ppm.

Provenance & Evidence