1-Bromo-3-chloropropane → HCID 86729478, compound

Participants

Reaction Steps

To a solution of tert-butyl octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate (1.21 g) in acetone (15 mL) was added K2CO3 (3.00 g) and 1-bromo-3-chloropropane (1.6 mL). The reaction mixture was heated to reflux for 7 h, diluted with water and extracted with EtOAc. The organic layer was dried over anhydrous Na2SO4 for 1 h and filtered. The filtrate was concentrated in vacuo and the residue was chromatographed with a silica gel column (eluting agent: 30:1 (v/v) CH2Cl2/MeOH) to afford the title compound as pale yellow liquid (1.20 g, 75.00%).

Provenance & Evidence