Hydrochloric Acid → HCID 71572442, compound

Participants

Reaction Steps

To a solution of tert-butyl 6-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy) propyl)octahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate (1.16 g) in the mixture solvent of CH2Cl2 and MeOH was added a solution of HCl in EtOAc (30 mL). The reaction mixture was stirred at room temperature for 4 h, and filtered to give the title compound as a solid (1.20 g, 100%), HPLC: 99.69%. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 486.2 (M+1); 1H NMR (400 MHz, CDCl3) δ: 1.45 (m, 2H), 1.78 (m, 3H), 1.80 (m, 2H), 2.10 (m, 1H), 2.42 (m, 5H), 2.82 (m, 3H), 4.03 (s, 3H), 4.10 (m, 2H), 6.76 (s, 1H), 7.16 (d, J=8.2 Hz, 1H), 7.24 (s, 1H), 7.28 (d, J=8.2 Hz, 1H), 7.41 (s, 1H), 8.54 (s, 1H) ppm.

Provenance & Evidence