1-Bromo-3-chloropropane → HCID 86729488, compound

Participants

Reaction Steps

To a solution of octahydropyrano[3,4-c]pyrrole (0.14 g) in acetone (30 mL) was added K2CO3 (0.76 g) followed by 1-chloro-3-bromopropane (0.57 g, 2.0 eq). The reaction mixture was heated to reflux for 12 h and filtered. The filtrate was concentrated in vacuo, and the residue was dissolved in EtOAc (100 mL). The solution was washed with water (100 mL×2) followed by brine (100 mL), dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was chromatographed with a silica gel column (eluting agent: 20:1 (v/v) EA/CH3OH) to give the title compound (38 mg, 16.96%). The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 204.7 (M+1).

Provenance & Evidence