1-Bromo-3-chloropropane → HCID 86729489, compound

Participants

Reaction Steps

A mixture of 3-methyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine (1.60 g), 1-bromo-3-chloropropane (3.50 mL) and cesium carbonate in acetone was heated to reflux for 24 h. The reaction mixture was cooled to room temperature and filtered. The filtrate was concentrated in vacuo and the residue was chromatographed with a silica gel column (eluting agent: 20:1 (v/v) DCM/MeOH) to give the title compound as yellow oil (0.97 g, 39.00%), HPLC: 85.00%. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 215.2 (M+1).

Provenance & Evidence