反应详情

温度

70 °C

To a solution of 6-ethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine (2.00 g) in glycol monomethyl ether was added a catalytic amount of 10% Pd/C. The suspension was heated to 70° C. and stirred for 6 h under H2 (2 MPa), then cooled to rt, and poured into 100 mL of water. The mixture was extracted with CH2Cl2 (50 mL×3). The combined organic phases were dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuo to give the title compound as yellow oil (1.50 g, 70.00%). The crude product was used for the next step without further purification. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 155.0 (M+1).

1. temperaturecooled to rt
2. extractionThe mixture was extracted with CH2Cl2 (50 mL×3)
3. dry with materialThe combined organic phases were dried over anhydrous Na2SO4
4. filtrationfiltered
5. concentrationThe filtrate was concentrated in vacuo