HCID 12189039, compound → HCID 10559756, compound

Participants

Reaction Steps

To a solution of (E)-ethyl 3-(3-(benzyloxy)pyridin-2-yl)acrylate (3.00 g) in MeOH was added a catalytic amount of 10% Pd/C. The reaction mixture was stirred for 2 h at room temperature under H2 and filtered. The filtrate was concentrated in vacuo to give the title compound as a yellow solid (1.34 g, 65.00%), and the crude product was used for the next step without further purification. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 196.1 (M+1); 1H NMR (400 MHz, CDCl3) δ: 9.41 (bs, 1H), 8.15-8.21 (m, 1H), 7.3-7.0 (m, 2H), 4.15-4.05 (m, 2H), 3.15 (t, J=4.2 Hz, 2H), 2.85 (t, J=8.0 Hz, 2H), 1.2 (t, J=4.2 Hz, 2H) ppm.

Provenance & Evidence