HCID 10559756, compound → HCID 12486248, compound

Participants

Reaction Steps

To a solution of LiAlH4 (0.94 g) in THF was added ethyl 3-(3-hydroxypyridin-2-yl)propanoate (2.40 g) slowly at 0° C. The reaction mixture was stirred for 5 h at room temperature under N2, then cooled to rt and quenched with water at 0° C. The mixture was filtered. The filtrate was concentrated in vacuo to give the compound as yellow oil (0.95 g, 50%), and the crude product was used for the next step without further purification. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 154.7 (M+1).

Provenance & Evidence