Potassium Hydroxide → HCID 86729513, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (3R,4R)-benzyl 3-(2-bromoethoxy)-4-hydroxypyrrolidine-1-carboxylate (0.20 g, 0.58 mmol) in EtOH (5 mL) was added a solution of KOH (32.0 mg, 0.58 mmol) in EtOH (5 mL). The reaction mixture was stirred for 0.5 h at 85° C., then quenched with water and extracted with CH2Cl2. The organic layer was dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was chromatographed with a silica gel column (eluting agent: 5:1 (v/v)PE/EtOAc) to give the title compound as colorless oil (0.11 g, 73.33%).

Provenance & Evidence