Hydrochloric Acid → HCID 71573030, compound

Participants

Reaction Steps

To a solution of tert-butyl 5-(3-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy) propyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (1.22 g) in DCM (30 mL) was added a solution of HCl in EtOAc at room temperature. The reaction mixture was stirred for 6 h at room temperature and filtered to give crude product. The crude product was recrystallized from a mixture of MeOH and EA to give the title compound as a white solid (0.91 g, 90.50%), HPLC: 94.65%. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 444.2 (M+1); 1H NMR (400 MHz, CDCl3) δ: 1.84-1.89 (m, 4H), 2.38-2.44 (m, 6H), 2.69-2.76 (m, 4H), 3.95 (s, 3H), 4.03 (s, 1H), 4.14 (t, J=7.2 Hz, 2H), 7.13 (s, 1H), 7.25 (s, 1H), 7.43 (s, 1H), 7.55-7.60 (m, 1H), 7.90-7.93 (m, 1H), 8.68 (s, 1H) ppm.

Provenance & Evidence