HCID 117667637, compound → HCID 117667561, compound

Participants

Reaction Steps

6-(5-Acetyl-pyridin-3-yl)-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester (500 mg, 1.4 mmol) is dissolved in 20 mL of 20% TFA in DCM. The mixture is stirred at room temperature for 16 hrs. Then the solvent and the extra reagent are removed and the residue is purified by reversed phase chromatography to give 135 mg of 1-[5-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-3-yl]-ethanone

Provenance & Evidence