Potassium Carbonate → HCID 86305713, compound

Participants

Reaction Steps

To a solution of 6-[5-(1-methyl-1H-indol-2-yl)-pyridin-3-yl]-1,2,3,4-tetrahydro-[1,8]naphthyridine (110 mg; 0.32 mmol) in anhydrous DCM (5.0 mL) is added benzoyl isocyanate (71 mg; 0.48 mmol). The mixture is heated to reflux for 3 hrs. The solvent is removed and the residue is dissolved in EtOH (5.0 ml). K2CO3 (76 mg; 0.55 mmol) is added and the mixture is heated to reflux for 1 hr. Then the solvent is removed and the residue is purified by preparative HPLC to give 74 mg of the titled product.

Provenance & Evidence