Pyridine → HCID 86305717, compound

Participants

Reaction Steps

To a solution of 7-(5-fluoro-pyridin-3-yl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine (350 mg, 1.5 mmol) (which is synthesized according to the procedure for Step 1 of Example 12) in DCM (100 mL) is added pyridine (1.7 g 18 mmol), then acetyl chloride (710 mg 9.1 mmol) is added dropwise. The solution is stirred at room temperature for 16 hrs and the solvent is removed. The residue is purified by preparative HPLC to give 54 mg of the titled product.

Provenance & Evidence