Trifluoroacetic acid → HCID 117667425, compound

Participants

Reaction Steps

[5-(8-Carbamoyl-5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-3-ylmethyl]-carbamic acid tert-butyl ester (100 mg, 0.26 mmol) is dissolved in 5.0 mL of DCM and trifluoroacetic acid (0.5 mL) is added. The mixture is stirred for 1 hr and the solvent is removed in vacuo. The residue is dissolved in MeOH and filtered through a StratoSpheres SPE cartridge (PL-HCO3 MP SPE) to remove the acid. The filtrate is then concentrated to give 75 mg of 6-(5-aminomethyl-pyridin-3-yl)-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide which is used in the next step without purification.

Provenance & Evidence