Ammonium formate → HCID 86305858, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 6-[5-(3,6-dihydro-2H-pyran-4-yl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide (42.0 mg, 0.13 mmol) and 10% Pd/C (42 mg) under Argon is added 2 mL of MeOH. Then ammonium formate (10 eq) is as added and the mixture stirred for 26 hrs at 80° C. The mixture is filtered, concentrated and purified by Preparative HPLC system (10%-80% CH3CN/H2O) to give 31.1 mg of the titled product.

Provenance & Evidence