HCID 117667606, compound → HCID 117667514, compound

Participants

Reaction Steps

6-(4-Methoxy-pyridin-3-yl)-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester (420 mg, 1.2 mmol) is dissolved in 20% trifluoroacetic acid in DCM (20 mL). The solution is stirred at room temperature for 16 hrs and then the solvent is removed. The residue is dissolved in DCM and saturated aqueous NaHCO3 solution is used to adjust the pH to 9˜10. The organic layer is separated, dried over Na2SO4, filtered and concentrated to give 290 mg of 6-(4-methoxy-pyridin-3-yl)-1,2,3,4-tetrahydro-[1,8]naphthyridine (290 mg crude) which is converted to 38 mg of the titled product according to the procedure of Urea Formation Method I.

Provenance & Evidence