Acetyl chloride → HCID 117667771, compound

Participants

Reaction Steps

To a solution of (3-bromopyridin-4-yl) methanamine (3.5 g, 19 mmol) in DCM (880 mL) is added Na2CO3 (3.0 g, 28 mmol), then acetyl chloride (1.6 g, 21 mmol) is added at 0° C. under N2 atmosphere. The mixture is stirred at room temperature for 3 hrs and then it is diluted with DCM. The mixture is washed with water and brine, dried over Na2SO4, filtered and concentrated to give the crude product. Purification by flash column chromatography affords 2.1 g of N-(3-Bromo-pyridin-4-ylmethyl)-acetamide.

Provenance & Evidence