Ammonium formate → HCID 117667759, compound

Participants

Reaction Conditions

Reaction Steps

To the mixture of 6-[5-(1,1-dioxo-1,2,3,6-tetrahydro-1lambda6-thiopyran-4-yl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide (56 mg, 0.15 mmol) and 10% Pd/C (17 mg) is added 2 mL of MeOH under Ar. Then ammonium formate (140 mg, 2.20 mmol) is added and the mixture is stirred for 1 hr at 80° C. The mixture is filtered, concentrated and purified via Preparative HPLC (10%-80% CH3CN/H2O) to give 30.2 mg of the titled product.

Provenance & Evidence