Potassium Carbonate → HCID 117667365, compound

Participants

Reaction Conditions

Reaction Steps

2-[5-(5,6,7,8-Tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-3-yl]-propan-2-ol (33 mg, 0.12 mmol) and benzoyl isocyanate (40 mg, 0.25 mmol) are mixed in 1.0 mL of DCM and the mixture is heated at 50° C. for 16 hrs. Then the solvent is removed and the residue is dissolved in 1.0 mL of EtOH. K2CO3 (29 mg, 0.21 mmol) is added and the mixture is heated at 80° C. for 2 hrs, cooled down to room temperature for 16 hrs and heated at 80° C. again for another 3 hrs. Then the solvent is removed and the residue is partitioned between water (15 mL) and EtOAc (25 mL). The aqueous layer is separated and extracted with EtOAc (2×30 mL). The organic layers are combined and concentrated to give the crude product. The crude is purified by flash column chromatography to give 12 mg of the titled product.

Provenance & Evidence