Ammonium formate → HCID 117667206, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-(1′-acetyl-1′,2′,3′,6′-tetrahydro-[3,4]bipyridinyl-5-yl)-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide (91 mg, 0.24 mmol) in 2.0 mL of MeOH is added 10% Pd/C (38 mg, 0.036 mmol). Then ammonium formate (60 mg, 0.96 mmol) is added and the mixture is stirred for 2 hrs at 80° C. The solid of the reaction mixture is filtered and the filtrate is concentrated to give the crude product. Purification by flash column chromatography affords 38 mg of 6-(1′-acetyl-1′,2′,3′,4′,5′,6′-hexahydro-[3,4]bipyridinyl-5-yl)-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide.

Provenance & Evidence