HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 117667152, compound → HCID 117667100, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 117667152 | HCID 117667152 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 117667100 | HCID 117667100 | 87.9% |
Reaction Steps
A solution of 6-(5-benzyloxy-pyridin-3-yl)-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester (790 mg, 1.9 mmol) in 20% TFA in DCM (21 mL) is stirred at room temperature for 16 h. The solvent is removed under vacuum to afford 6-(5-benzyloxy-pyridin-3-yl)-1,2,3,4-tetrahydro-[1,8]naphthyridine (530 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181272B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-50ed47ec8d5c4db2b00bee6c95c6999a |
| Source note | uspto-grants-2015_11 |