HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 117667312, compound → HCID 117667108, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 117667312 | HCID 117667312 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 117667108 | HCID 117667108 | 100.5% |
Reaction Steps
A stirred suspension of 6-(5-benzyloxy-pyridin-3-yl)-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide (167 mg, 0.46 mmol) in EtOH (10 mL) is hydrogenated over 10% palladium on carbon (17 mg) under balloon pressure for 16 h. The catalyst is removed by filtration through diatomaceous earth, washing well with DCM. The solvent is evaporated to afford the title compound (125 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181272B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-dcbf355a098842118ad34311da439492 |
| Source note | uspto-grants-2015_11 |