HuagongsheHuagongshe Chemistry Print Report · For research reference only
Urea → HCID 117667099, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 117667234 | HCID 117667234 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 117667099 | HCID 117667099 | — |
| Product | HCID 117667234 | HCID 117667234 | — |
Reaction Steps
1-{4-[5-(5,6,7,8-Tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-3-yloxy]-piperidin-1-yl}-ethanone is synthesized according to the procedure for Step 2 of Example 27 using 20% trifluoroacetic acid in DCM as the reagent. 1-{4-[5-(5,6,7,8-Tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-3-yloxy]-piperidin-1-yl}-ethanone (200 mg, 0.57 mmol) is converted to 34 mg of the titled product according to the procedure of Urea Formation Method I.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181272B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-b78a5d717c9b4976a1bdbc815eabce39 |
| Source note | uspto-grants-2015_11 |