HCID 123135825, compound → HCID 117667711, compound

Participants

Reaction Steps

5% Pd on carbon (150 mg, 0.07 mmol) is added to a solution of 6-[5-(-3-methanesulfonyl-propenyl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester (340 mg, 0.79 mmol) in MeOH (30 mL). The mixture is stirred at room temperature under H2 atmosphere of 40 PSI for 16 hrs. After filtration, the filtrate is concentrated to give 240 mg of 6-[5-(3-methanesulfonyl-propyl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester. This is then used to prepare 6-[5-(3-methanesulfonyl-propyl)-pyridin-3-yl]-1,2,3,4-tetrahydro-[1,8]naphthyridine according to the procedure for Step 2 of Example 27 using 20% trifluoroacetic acid in DCM as the reagent.

Provenance & Evidence